Human Frontier Science Program- Research Grant 2025

The Human Frontier Science Program (HFSP) is now accepting applications for its Research Grants 2025. These grants are designed to support international and interdisciplinary collaborations in life sciences, with a focus on high-risk, high-reward projects that push the boundaries of scientific understanding. The HFSP encourages pioneering research that brings together scientists from diverse disciplines to explore fundamental biological questions in innovative ways.

This funding opportunity is aimed at both established researchers and early-career scientists seeking to develop new lines of research with global collaborators.


Types of Research Grants Available

HFSP offers two distinct types of research grants:

Grant TypeDescription
Research Grants – ProgramSupports international teams of independent researchers who aim to collaborate on developing new research directions. Teams should be composed of scientists with expertise in different areas of life sciences or complementary disciplines.
Research Grants – Early CareerDesigned for early-career researchers who have recently obtained an independent position. Applicants must be within five years of starting their independent career and should propose original research that ventures into unexplored scientific territory.

Early-career scientists are encouraged to use this funding by Human Frontier Science Program to establish themselves as independent researchers while contributing to global scientific advancements.


Eligibility and Team Composition

HFSP strongly encourages projects that involve international collaboration and interdisciplinary approaches. To be eligible, applicants must meet the following criteria:

  • Research teams must consist of at least two and up to four members.
  • Each team must have one Principal Applicant and one or more Co-Applicants, who are independent researchers from different institutions.
  • Applicants must be affiliated with research institutions, universities, or non-profit organizations.
  • Individual researchers cannot apply alone—only research teams with members from at least two different countries are eligible.
  • Research must focus on fundamental biological questions. Projects involving applied research, such as drug development or clinical trials, are not eligible.

HFSP particularly encourages proposals that bring together scientists from diverse disciplines, including those from fields outside traditional life sciences, such as physics, chemistry, mathematics, engineering, and computer science.


Scientific Scope and Research Focus

HFSP Research Grants aim to support studies that:

  • Investigate fundamental problems in life sciences that require fresh perspectives.
  • Encourage collaborations between scientists from different disciplines, such as biologists working with physicists or computer scientists.
  • Address challenging scientific questions through innovative and experimental approaches.
  • Have the potential to transform current scientific understanding through high-risk, high-reward research.

The program seeks proposals that do not simply extend ongoing research, but rather explore novel and previously untested ideas. Research that bridges multiple scientific disciplines and introduces new conceptual frameworks is highly valued.


Funding Details and Grant Duration

HFSP grants provide significant financial support based on team size. The funding structure is as follows:

Team SizeAnnual Funding (USD)
2 members$300,000
3 members$400,000
4 members$500,000
  • The grant duration is three years.
  • Each research team must be composed of members from different countries to receive the full funding.

HFSP funding covers research-related costs, including salaries, consumables, travel expenses, and small equipment purchases. The funds are intended to support the research process, enabling scientists to work collaboratively across international borders.


Application Timeline and Review Process

The HFSP Research Grant selection process follows a two-stage review system, beginning with the submission of a Letter of Intent (LOI).

StageDeadline
Letter of Intent (LOI) Submission OpensMarch 18, 2025
LOI Submission DeadlineMarch 27, 2025
Invitation for Full Proposal Submission (Selected Applicants Only)Mid-September 2025
Final Award Decision AnnouncementMarch 2026
1st Step: Letter of Intent (LOI) Submission
  • Applicants must submit a preliminary proposal outlining their research objectives and team composition.
2nd Step: Full Proposal Submission (Invitation Only)
  • Shortlisted applicants will submit a detailed research proposal, including methodology, expected outcomes, and budget plans.
3rd Step: Award Announcement
  • HFSP will announce the final grant recipients in March 2026.
  • Funded projects will begin shortly after the award announcement.

How to Apply

Researchers interested in applying must visit the official HFSP website and follow the guidelines for submission. The application portal provides detailed instructions on eligibility, formatting requirements, and review criteria.

For full details and submission instructions, visit:
HFSP Research Grants Portal

Applicants should carefully review all eligibility requirements before submitting their LOI, as incomplete or non-compliant applications will not be considered.


Why Apply for an HFSP Research Grant?

  • Encourages International Collaboration – Researchers from different countries can form teams to address complex biological challenges.
  • Supports Groundbreaking Research – HFSP funds high-risk, high-reward projects that may not fit within conventional funding schemes.
  • Significant Financial Support – Teams can receive up to $500,000 per year, ensuring ample resources for innovative research.
  • Enhances Career Growth – Especially for early-career scientists, an HFSP grant can serve as a springboard for career advancement.
  • Promotes Interdisciplinary Approaches – Scientists from non-biological fields can contribute to fundamental life science research.

HFSP grants provide a unique opportunity for researchers to collaborate on a global scale while conducting cutting-edge scientific investigations.

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